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Search: WFRF:(Persson L Jenny) > Persson Jenny L. > The METTL3 RNA Meth...

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer

Haigh, Daisy B. (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.
Woodcock, Corinne L. (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.
Lothion-Roy, Jennifer (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.
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Harris, Anna E. (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.
Metzler, Veronika M. (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.
Persson, Jenny L., Professor (author)
Malmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Malmö Universitet, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Umea Univ, Dept Mol Biol, S-90187 Umea, Sweden.
Robinson, Brian D. (author)
Department of Pathology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pathol, New York, NY 10065 USA.
Khani, Francesca (author)
Department of Pathology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pathol, New York, NY 10065 USA.
Alsaleem, Mansour (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Applied Medical Science, Applied College, Qassim University, Qassim, Unayzah, Saudi Arabia,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Med, Nottingham NG7 2RD, England.;Qassim Univ, Appl Coll, Dept Appl Med Sci, Unayzah 51911, Saudi Arabia.
Ntekim, Atara (author)
School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom; Department of Radiation Oncology, University College Hospital, University of Ibadan, Ibadan, Nigeria,Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.;Univ Ibadan, Univ Coll Hosp, Dept Radiat Oncol, Ibadan 200132, Nigeria.
Madhusudan, Srinivasan (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Medicine, University of Nottingham, Nottingham, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Med, Nottingham NG7 2RD, England.
Davis, Melissa B. (author)
Department of Surgery, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Surg, New York, NY 10065 USA.
Laursen, Kristian B. (author)
Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA.
Gudas, Lorraine J. (author)
Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA.
Rutland, Catrin S. (author)
School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.
Toss, Michael S. (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Medicine, University of Nottingham, Nottingham, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Med, Nottingham NG7 2RD, England.
Archer, Nathan (author)
School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.
Bodi, Zsuzsanna (author)
School of Biosciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, England.
Rakha, Emad A. (author)
School of Medicine, University of Nottingham, Nottingham, United Kingdom,Univ Nottingham, Sch Med, Nottingham NG7 2RD, England.
Fray, Rupert G. (author)
School of Biosciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, England.
Jeyapalan, Jennie N. (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.
Mongan, Nigel P. (author)
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom; Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.;Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA.
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Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (creator_code:org_t)
2022-10-20
2022
English.
In: Cancers. - : MDPI. - 2072-6694. ; 14:20
Related links:
https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
https://mau.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.3...
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing androgen biosynthesis or via AR signalling inhibition (ARSi) are common treatments. The N6-methyladenosine (m6A) RNA modification is involved in regulating mRNA expression, translation, and alternative splicing, and through these mechanisms has been implicated in cancer development and progression. RNA-m6A is dynamically regulated by the METTL3 RNA methyltransferase complex and the FTO and ALKBH5 demethylases. While there is evidence supporting a role for aberrant METTL3 in many cancer types, including localised PCa, the wider contribution of METTL3, and by inference m6A, in androgen signalling in PCa remains poorly understood. Therefore, the aim of this study was to investigate the expression of METTL3 in PCa patients and study the clinical and functional relevance of METTL3 in PCa. It was found that METTL3 is aberrantly expressed in PCa patient samples and that siRNA-mediated METTL3 knockdown or METTL3-pharmacological inhibition significantly alters the basal and androgen-regulated transcriptome in PCa, which supports targeting m6A as a novel approach to modulate androgen signalling in PCa.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

androgen receptor
endocrine driven cancer
m6A
METTL3
molecular signalling
prostate cancer
RNA methylation
therapeutic

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